Mixture of Indomethacin + Methyl Alcohol + Niacinamide

Datasets

1. Mass fraction (20)

Mass fraction of Niacinamide (3) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Fixed		Measured
Temperature, K - Liquid	Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	0.0000	0.2556
313.15	0.0000	0.3640
298.15	0.0248	0.2501
313.15	0.0537	0.3560

Mass fraction of Niacinamide (3) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Fixed		Measured
Temperature, K - Liquid	Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	0.0248	0.2501
298.15	0.0243	0.2471
298.15	0.0256	0.1716
298.15	0.0263	0.1496
298.15	0.0290	0.1105
298.15	0.0318	0.0880
298.15	0.0317	0.0875
313.15	0.0537	0.3560
313.15	0.0545	0.3491
313.15	0.0597	0.2748
313.15	0.0630	0.2498
313.15	0.0696	0.1996
313.15	0.0722	0.1879
313.15	0.0796	0.1680
313.15	0.0891	0.1367
313.15	0.0955	0.1268
313.15	0.0984	0.1237

Mass fraction of Niacinamide (3) [ref]

Operational conditions:

• Temperature, K = 298.15 (Liquid)
• Pressure, kPa = 101.3 (Liquid)

Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
0.0317	0.0875
0.0287	0.0772
0.0272	0.0525
0.0234	0.0320
0.0227	0.0183
0.0218	0.0113
0.0203	0.0074
0.0201	0.0047
0.0203	0.0031
0.0196	0.0018
0.0188	0.0013
0.0201	0.0000

Mass fraction of Niacinamide (3) [ref]

Operational conditions:

• Temperature, K = 313.15 (Liquid)
• Pressure, kPa = 101.3 (Liquid)

Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
0.0984	0.1237
0.0620	0.0540
0.0485	0.0267
0.0449	0.0000

Mass fraction of Niacinamide (3) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	101.30	0.0875

Mass fraction of Indomethacin (1) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Indomethacin (1) - Liquid
298.15	101.30	0.0317

Mass fraction of Niacinamide (3) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Temperature, K - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	0.2501
313.15	0.3560

Mass fraction of Indomethacin (1) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Temperature, K - Liquid	Mass fraction of Indomethacin (1) - Liquid
298.15	0.0248
313.15	0.0537

Mass fraction of Niacinamide (3) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	101.30	0.1237

Mass fraction of Indomethacin (1) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Indomethacin (1) - Liquid
298.15	101.30	0.0984

Mass fraction of Niacinamide (3) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Fixed		Measured
Temperature, K - Liquid	Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	0.0000	0.2556
313.15	0.0000	0.3640
298.15	0.0248	0.2501
313.15	0.0537	0.3560

Mass fraction of Niacinamide (3) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Fixed		Measured
Temperature, K - Liquid	Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	0.0248	0.2501
298.15	0.0243	0.2471
298.15	0.0256	0.1716
298.15	0.0263	0.1496
298.15	0.0290	0.1105
298.15	0.0318	0.0880
298.15	0.0317	0.0875
313.15	0.0537	0.3560
313.15	0.0545	0.3491
313.15	0.0597	0.2748
313.15	0.0630	0.2498
313.15	0.0696	0.1996
313.15	0.0722	0.1879
313.15	0.0796	0.1680
313.15	0.0891	0.1367
313.15	0.0955	0.1268
313.15	0.0984	0.1237

Mass fraction of Niacinamide (3) [ref]

Operational conditions:

• Temperature, K = 298.15 (Liquid)
• Pressure, kPa = 101.3 (Liquid)

Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
0.0317	0.0875
0.0287	0.0772
0.0272	0.0525
0.0234	0.0320
0.0227	0.0183
0.0218	0.0113
0.0203	0.0074
0.0201	0.0047
0.0203	0.0031
0.0196	0.0018
0.0188	0.0013
0.0201	0.0000

Mass fraction of Niacinamide (3) [ref]

Operational conditions:

• Temperature, K = 313.15 (Liquid)
• Pressure, kPa = 101.3 (Liquid)

Mass fraction of Indomethacin (1) - Liquid	Mass fraction of Niacinamide (3) - Liquid
0.0984	0.1237
0.0620	0.0540
0.0485	0.0267
0.0449	0.0000

Mass fraction of Niacinamide (3) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	101.30	0.0875

Mass fraction of Indomethacin (1) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Indomethacin (1) - Liquid
298.15	101.30	0.0317

Mass fraction of Niacinamide (3) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Temperature, K - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	0.2501
313.15	0.3560

Mass fraction of Indomethacin (1) [ref]

Operational condition: Pressure, kPa = 101.3 (Liquid)

Temperature, K - Liquid	Mass fraction of Indomethacin (1) - Liquid
298.15	0.0248
313.15	0.0537

Mass fraction of Niacinamide (3) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Niacinamide (3) - Liquid
298.15	101.30	0.1237

Mass fraction of Indomethacin (1) [ref]

Fixed		Measured
Temperature, K - Liquid	Pressure, kPa - Liquid	Mass fraction of Indomethacin (1) - Liquid
298.15	101.30	0.0984

Sources

• (Solid + liquid) phase diagram for (indomethacin + nicotinamide)- methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 (indomethacin + nicotinamide) co-crystal at T = (298.15 and 313.15) K