Chemical Properties of Salicylic acid (CAS 69-72-7)

InChI

InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI Key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

Formula

C7H6O3

SMILES

O=C(O)c1ccccc1O

Molecular Weight¹

138.12

CAS

69-72-7

Other Names

• 2-Carboxyphenol
• 2-Hydroxybenzenecarboxylic acid
• 2-hydroxybenzoic acid
• 7681-06-3
• 8052-31-1
• Acido salicilico
• Advanced pain relief callus removers
• Advanced pain relief corn removers
• Benzoic acid, o-hydroxy-
• Clear away wart remover
• Compound W
• Domerine
• Dr. Scholl's Callus Removers
• Dr. Scholl's Corn Removers
• Dr. Scholl's Wart Remover Kit
• Duofil Wart Remover
• Duofilm
• Duoplant
• Fostex
• Freezone
• Ionil
• Ionil plus
• Keralyt
• Kyselina 2-hydroxybenzoova
• Kyselina salicylova
• NSC 180
• Orthohydroxybenzoic acid
• Pernox
• Psoriacid-S-Stift
• Retarder SAX
• Retarder W
• Rutranex
• Salicyclic acid
• Salicylic acid & Sulfur Soap
• Salicylic acid collodion
• Salicylic acid soap
• Saligel
• Salonil
• Sebucare
• Sebulex
• Stri-Dex
• Trans-Ver-Sal
• benzoic acid, 2-hydroxy-
• component of Fostex medicated bar and cream
• component of Keralyt
• component of Solarcaine first aid spray
• component of Tinver
• o-Carboxyphenol
• o-hydroxybenzoic acid
• phenol-2-carboxylic acid

• ω : Acentric Factor.
• Δ_cH°_solid : Standard solid enthalpy of combustion (kJ/mol).
• C_p,gas : Ideal gas heat capacity (J/mol×K).
• C_p,solid : Solid phase heat capacity (J/mol×K).
• η : Dynamic viscosity (Pa×s).
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fH°_solid : Solid phase enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• Δ_subH° : Enthalpy of sublimation at standard conditions (kJ/mol).
• Δ_subH : Enthalpy of sublimation at a given temperature (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• Δ_vapH : Enthalpy of vaporization at a given temperature (kJ/mol).
• IE : Ionization energy (eV).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• P_vap : Vapor pressure (kPa).
• I_np : Non-polar retention indices.
• Δ_fusS : Entropy of fusion at a given temperature (J/mol×K).
• S°_{solid,1 bar} : Solid phase molar entropy at standard conditions (J/mol×K).
• T_boil : Normal Boiling Point Temperature (K).
• T_boilr : Boiling point at reduced pressure (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ω	0.7442		Relay (1.0) Calculated Property
ΔcH°solid	[-3029.60; -3020.00]	kJ/mol
ΔcH°solid	-3020.00 ± 1.30	kJ/mol	NIST
ΔcH°solid	-3022.40 ± 0.50	kJ/mol	NIST
ΔcH°solid	-3024.70	kJ/mol	NIST
ΔcH°solid	-3024.70	kJ/mol	NIST
ΔcH°solid	-3025.00	kJ/mol	NIST
ΔcH°solid	-3023.60	kJ/mol	NIST
ΔcH°solid	-3026.80	kJ/mol	NIST
ΔcH°solid	-3026.80	kJ/mol	NIST
ΔcH°solid	-3029.60	kJ/mol	NIST
ΔcH°solid	-3029.00 ± 0.40	kJ/mol	NIST
ΔcH°solid	-3027.29	kJ/mol	NIST
ΔcH°solid	-3022.90	kJ/mol	NIST
ΔfG°	-299.89	kJ/mol	Joback Calculated Property
ΔfH°gas	[-495.80; -489.00]	kJ/mol
ΔfH°gas	-495.80 ± 1.40	kJ/mol	NIST
ΔfH°gas	-493.40	kJ/mol	NIST
ΔfH°gas	-489.00	kJ/mol	NIST
ΔfH°solid	[-592.10; -585.30]	kJ/mol
ΔfH°solid	-592.10 ± 1.30	kJ/mol	NIST
ΔfH°solid	-589.70 ± 1.10	kJ/mol	NIST
ΔfH°solid	-585.30	kJ/mol	NIST
ΔfusH°	[24.06; 27.09]	kJ/mol
ΔfusH°	24.06	kJ/mol	Solubility of salicylic acid in pure alcohols at different temperatures
ΔfusH°	27.09	kJ/mol	Solubility and Melting Properties of Salicylic Acid
ΔsubH°	[81.75; 96.30]	kJ/mol
ΔsubH°	94.40 ± 0.40	kJ/mol	NIST
ΔsubH°	96.27 ± 0.49	kJ/mol	NIST
ΔsubH°	96.30	kJ/mol	NIST
ΔsubH°	96.30 ± 0.50	kJ/mol	NIST
ΔsubH°	95.70 ± 0.10	kJ/mol	NIST
ΔsubH°	95.10 ± 0.40	kJ/mol	NIST
ΔsubH°	Outlier 81.75	kJ/mol	NIST
ΔvapH°	82.22	kJ/mol	Relay (1.0) Calculated Property
IE	8.59	eV	Relay (1.0) Calculated Property
log10WS	[-1.93; -1.85]
log10WS	-1.85		Aq. Solubility Prediction
log10WS	-1.93		Aq. Solubility Prediction
logPoct/wat	1.090		Crippen Calculated Property
McVol	99.040	ml/mol	McGowan Calculated Property
Pc	6349.11	kPa	Joback Calculated Property
Inp	[1263.00; 1342.00]
Inp	1277.00		NIST
Inp	1266.00		NIST
Inp	1296.00		NIST
Inp	1305.00		NIST
Inp	1326.00		NIST
Inp	1308.00		NIST
Inp	1308.00		NIST
Inp	1330.00		NIST
Inp	1295.80		NIST
Inp	1311.00		NIST
Inp	1291.00		NIST
Inp	1263.00		NIST
Inp	1330.00		NIST
Inp	1330.00		NIST
Inp	1294.00		NIST
Inp	1342.00		NIST
Inp	1308.00		NIST
Inp	1277.00		NIST
Inp	1295.80		NIST
Inp	1311.00		NIST
Inp	1294.00		NIST
S°solid,1 bar	[172.40; 178.20]	J/mol×K
S°solid,1 bar	172.40	J/mol×K	NIST
S°solid,1 bar	178.20	J/mol×K	NIST
Tboil	538.63	K	Relay (1.0) Calculated Property
Tc	822.88	K	Relay (1.0) Calculated Property
Tfus	[430.00; 432.70]	K
Tfus	432.15	K	Liquid pharmaceuticals formulation by eutectic formation
Tfus	432.70	K	Abraham model correlations for describing the thermodynamic properties of solute transfer into pentyl acetate based on headspace chromatographic and solubility measurements
Tfus	432.00	K	Polar Mixed-Solid Solute Systems in Supercritical Carbon Dioxide: Entrainer Effect and Its Influence on Solubility and Selectivity
Tfus	431.92	K	Aq. Solubility Prediction
Tfus	431.92	K	Aq. Solubility Prediction
Tfus	432.00 ± 1.50	K	NIST
Tfus	431.45 ± 0.50	K	NIST
Tfus	Outlier 430.00 ± 4.00	K	NIST
Tfus	432.10 ± 0.80	K	NIST
Tfus	432.00 ± 0.80	K	NIST
Tfus	432.10 ± 0.80	K	NIST
Tfus	432.20 ± 0.80	K	NIST
Vc	0.342	m3/kmol	Relay (1.0) Calculated Property

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[233.10; 269.96]	J/mol×K	[612.91; 833.23]
Cp,gas	233.10	J/mol×K	612.91	Joback Calculated Property
Cp,gas	240.40	J/mol×K	649.63	Joback Calculated Property
Cp,gas	247.14	J/mol×K	686.35	Joback Calculated Property
Cp,gas	253.40	J/mol×K	723.07	Joback Calculated Property
Cp,gas	259.25	J/mol×K	759.79	Joback Calculated Property
Cp,gas	264.74	J/mol×K	796.51	Joback Calculated Property
Cp,gas	269.96	J/mol×K	833.23	Joback Calculated Property
Cp,solid	[104.20; 177.50]	J/mol×K	[280.40; 405.50]
Cp,solid	128.50	J/mol×K	280.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	130.00	J/mol×K	285.50	Determination of the activity of a molecular solute in saturated solution
Cp,solid	159.40	J/mol×K	288.60	NIST
Cp,solid	131.60	J/mol×K	290.50	Determination of the activity of a molecular solute in saturated solution
Cp,solid	104.20	J/mol×K	293.00	NIST
Cp,solid	133.50	J/mol×K	295.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	160.90	J/mol×K	298.15	NIST
Cp,solid	135.40	J/mol×K	300.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	137.40	J/mol×K	305.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	139.40	J/mol×K	310.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	141.40	J/mol×K	315.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	143.50	J/mol×K	320.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	145.50	J/mol×K	325.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	147.60	J/mol×K	330.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	149.80	J/mol×K	335.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	151.80	J/mol×K	340.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	154.10	J/mol×K	345.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	156.20	J/mol×K	350.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	158.20	J/mol×K	355.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	160.30	J/mol×K	360.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	162.30	J/mol×K	365.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	164.20	J/mol×K	370.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	165.90	J/mol×K	375.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	168.00	J/mol×K	380.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	170.10	J/mol×K	385.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	172.10	J/mol×K	390.40	Determination of the activity of a molecular solute in saturated solution
Cp,solid	173.80	J/mol×K	395.50	Determination of the activity of a molecular solute in saturated solution
Cp,solid	175.60	J/mol×K	400.50	Determination of the activity of a molecular solute in saturated solution
Cp,solid	177.50	J/mol×K	405.50	Determination of the activity of a molecular solute in saturated solution
η	[0.0000161; 0.0010587]	Pa×s	[417.54; 612.91]
η	0.0010587	Pa×s	417.54	Joback Calculated Property
η	0.0004096	Pa×s	450.10	Joback Calculated Property
η	0.0001801	Pa×s	482.66	Joback Calculated Property
η	0.0000879	Pa×s	515.23	Joback Calculated Property
η	0.0000467	Pa×s	547.79	Joback Calculated Property
η	0.0000266	Pa×s	580.35	Joback Calculated Property
η	0.0000161	Pa×s	612.91	Joback Calculated Property
ΔfusH	[23.05; 27.10]	kJ/mol	[431.10; 434.10]
ΔfusH	24.45	kJ/mol	431.10	NIST
ΔfusH	24.60	kJ/mol	431.80	NIST
ΔfusH	24.60	kJ/mol	431.80	NIST
ΔfusH	23.05	kJ/mol	432.50	NIST
ΔfusH	27.10	kJ/mol	434.10	NIST
ΔsubH	[93.20; 99.00]	kJ/mol	[313.00; 388.00]
ΔsubH	99.00 ± 2.00	kJ/mol	313.00	NIST
ΔsubH	95.70 ± 0.80	kJ/mol	315.50	NIST
ΔsubH	95.70 ± 0.80	kJ/mol	315.50	NIST
ΔsubH	94.90 ± 0.40	kJ/mol	322.00	NIST
ΔsubH	93.20 ± 0.80	kJ/mol	322.00	NIST
ΔsubH	95.10 ± 0.50	kJ/mol	333.00	NIST
ΔsubH	94.80 ± 0.40	kJ/mol	388.00	NIST
ΔsubH	95.10 ± 0.40	kJ/mol	388.00	NIST
ΔvapH	79.40	kJ/mol	474.50	NIST
ΔfusS	56.90	J/mol×K	431.80	NIST

Pressure Dependent Properties

Correlations

Property	Value	Unit	Temperature (K)	Source
Pvap	[2.71; 6185.51]	kPa	[431.75; 739.00]	KDB Vapor Pressure Data
Equation			ln(Pvp) = A + B/T + C*ln(T) + D*T^2
Coefficient A			4.74158e+02
Coefficient B			-3.34417e+04
Coefficient C			-6.61599e+01
Coefficient D			3.08189e-05
Temperature range, min.			431.75
Temperature range, max.			739.00
Pvap	2.71	kPa	431.75	Calculated Property
Pvap	13.24	kPa	465.89	Calculated Property
Pvap	45.69	kPa	500.03	Calculated Property
Pvap	123.34	kPa	534.17	Calculated Property
Pvap	280.60	kPa	568.31	Calculated Property
Pvap	568.93	kPa	602.44	Calculated Property
Pvap	1072.29	kPa	636.58	Calculated Property
Pvap	1940.48	kPa	670.72	Calculated Property
Pvap	3457.41	kPa	704.86	Calculated Property
Pvap	6185.51	kPa	739.00	Calculated Property

Similar Compounds

Find more compounds similar to Salicylic acid.

Mixtures

• Choline chloride + Salicylic acid
• Salicylic acid + Water
• sodium chloride + Salicylic acid + Water
• potassium chloride + Salicylic acid + Water
• Sodium bromide + Salicylic acid + Water
• Salicylic acid + Water + Potassium sulfate
• Sodium sulfate + Salicylic acid + Water
• Salicylic acid + Water + TRIPENTYL PHOSPHATE
• Ethanol + Salicylic acid
• 1-Propanol + Salicylic acid
• Salicylic acid + 1-Butanol
• Salicylic acid + 1-Pentanol
• Salicylic acid + 1-Hexanol
• Acetic acid, pentyl ester + Salicylic acid
• 1-Propanol + Salicylic acid + Water
• 2-Propanol + Salicylic acid
• Salicylic acid + Acetone
• 2-Propanol + Salicylic acid + Water
• Salicylic acid + Acetone + Water
• Carbon dioxide + Salicylic acid

Find more mixtures with Salicylic acid.

Sources

• KDB Vapor Pressure Data
• Cheméo Relay (1.0)
• Crippen Method
• Solubility of salicylic acid in water + salt (NaCl, KCl, NaBr, Na2SO4 and K2SO4) at 293.5 to 313.3 K
• Liquid pharmaceuticals formulation by eutectic formation
• Strategy for extractant residual reduction: Experimental and computational investigation of fluorinated phosphate
• Construction, calibration and testing of a micro-combustion calorimeter
• Determination of the activity of a molecular solute in saturated solution
• Solubility of salicylic acid in pure alcohols at different temperatures
• Calibration and testing of an isoperibolic micro-combustion calorimeter developed to measure the enthalpy of combustion of organic compounds containing C, H, O and N
• Abraham model correlations for describing the thermodynamic properties of solute transfer into pentyl acetate based on headspace chromatographic and solubility measurements
• Synthesis, characterization and standard molar enthalpy of formation of La(C7H5O3)2*(C9H6NO)
• Synthesis, Characterization and Standard Molar Enthalpy of Formation of Sm (C7H5O3)2 * (C9H6NO)
• Thermochemical Analysis on Rare Earth Complex of Gadolinium with Salicylic acid and 8-hydroxyquinoline
• Solubility of 4-Methylsulfonylacetophenone in Nine Pure Solvents and (Ethyl Acetate + n-Hexane) Binary Solvent Mixtures from 278.15 K to 328.15 K
• Measurement and Correlation of the Solubility of 2,6-Dihydroxybenzoic Acid in Alcohols and Binary Solvents
• Solubility of Benzoin in Six Monosolvents and in Some Binary Solvent Mixtures at Various Temperatures
• Determination and Correlation of Solubility and Thermodynamic Properties of trans-Cinnamyl Alcohol in Pure and Binary Solvents from 253.15 K to 293.15 K
• Solubility and Melting Properties of Salicylic Acid
• Solubility of 2-Hydroxybenzoic Acid in Water, 1-Propanol, 2-Propanol, and 2-Propanone at (298.2 to 338.2) K and Their Aqueous Binary Mixtures at 298.2 K
• Solubility of Glycyrrhizin in supercritical carbon dioxide with and without cosolvent
• Polar Mixed-Solid Solute Systems in Supercritical Carbon Dioxide: Entrainer Effect and Its Influence on Solubility and Selectivity
• Solubility of Salicylic Acid in Water, Ethanol, Carbon Tetrachloride, Ethyl Acetate, and Xylene
• Solubilities of Salicylic Acid in Pure Solvents and Binary Mixtures Containing Cosolvent
• Solubility of Benzoic and Salicylic Acids in Subcritical Water at Temperatures Ranging from (298 to 473) K
• Joback Method
• Aqueous Solubility Prediction Method
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

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Outlier This icon means that the value is more than 2 standard deviations away from the property mean.