Chemical Properties of Ethosuximide (CAS 77-67-8)

InChI

InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI Key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Formula

C7H11NO2

SMILES

CCC1(C)CC(=O)NC1=O

Molecular Weight¹

141.17

CAS

77-67-8

Other Names

• (.+-.)-Ethosuximide
• (.+/-.)-Ethosuximide
• 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-
• 2-Methyl-2-ethylsuccinimide
• 2-ethyl-2-methylsuccinimide
• 3-Ethyl-3-methyl-2,5-pyrrolidinedione
• 3-Ethyl-3-methylpyrroline-2,5-dione
• 3-Methyl-3-ethylpyrrolidine-2,5-dione
• 3-Methyl-3-ethylsuccinimide
• 3-ethyl-3-methylpyrrolidine-2,5-dione
• Aethosuximide
• Asamid
• Atysmal
• C.I. 366
• CI-366
• CN-10,395
• Capitus
• Cl 366
• Emeside
• Epileo petit mal
• Ethosuccimide
• Ethosuccinimide
• Ethosuxide
• Ethymal
• Etomal
• Etosuximid
• Etosuximida
• H 940
• H-490
• Mesentol
• NSC-64013
• PM 671
• Pemal
• Pemalin
• Pentinimid
• Peptinimid
• Petinimid
• Petnidan
• Piknolepsin
• Pyknolepsinum
• Ronton
• Simatin
• Simatin(E)
• Succimal
• Succimitin
• Succinimide, 2-ethyl-2-methyl-
• Suxilep
• Suximal
• Suxin
• Suxinutin
• Thetamid
• Thilopemal
• Uritone
• Urodeine
• Zaraondan
• Zarodan
• Zarondan
• Zarondan-Saft
• Zarontin
• Zartalin
• «alpha»-Ethyl-«alpha»-methylsuccinimide
• «alpha»-Methyl-«alpha»-ethylsuccinimide
• «gamma»-Methyl-«gamma»-ethylsuccinimide

• ω : Acentric Factor.
• C_p,gas : Ideal gas heat capacity (J/mol×K).
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• IE : Ionization energy (eV).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• I_np : Non-polar retention indices.
• T_boil : Normal Boiling Point Temperature (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ω	0.4582		Relay (1.0) Calculated Property
ΔfG°	-118.35	kJ/mol	Joback Calculated Property
ΔfH°gas	-442.05	kJ/mol	Relay (1.0) Calculated Property
ΔfusH°	10.13	kJ/mol	Joback Calculated Property
ΔvapH°	64.10	kJ/mol	Relay (1.0) Calculated Property
IE	9.78	eV	Relay (1.0) Calculated Property
log10WS	-0.91		Relay (1.0) Calculated Property
logPoct/wat	0.449		Crippen Calculated Property
McVol	111.750	ml/mol	McGowan Calculated Property
Pc	4056.96	kPa	Joback Calculated Property
Inp	[1189.00; 1225.00]
Inp	1196.00		NIST
Inp	1190.00		NIST
Inp	1210.00		NIST
Inp	1225.00		NIST
Inp	1192.00		NIST
Inp	1193.00		NIST
Inp	1193.00		NIST
Inp	1194.00		NIST
Inp	1194.00		NIST
Inp	1193.00		NIST
Inp	1220.00		NIST
Inp	1189.00		NIST
Inp	1220.00		NIST
Inp	1220.00		NIST
Inp	1206.00		NIST
Inp	1189.00		NIST
Inp	1206.00		NIST
Inp	1196.00		NIST
Tboil	517.34	K	Relay (1.0) Calculated Property
Tc	727.53	K	Relay (1.0) Calculated Property
Tfus	316.71	K	Experimental measurement and correlation of solubility of ethosuximide in supercritical carbon dioxide
Vc	0.392	m3/kmol	Relay (1.0) Calculated Property

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[270.91; 349.04]	J/mol×K	[559.27; 806.65]
Cp,gas	270.91	J/mol×K	559.27	Joback Calculated Property
Cp,gas	285.39	J/mol×K	600.50	Joback Calculated Property
Cp,gas	299.21	J/mol×K	641.73	Joback Calculated Property
Cp,gas	312.42	J/mol×K	682.96	Joback Calculated Property
Cp,gas	325.08	J/mol×K	724.19	Joback Calculated Property
Cp,gas	337.27	J/mol×K	765.42	Joback Calculated Property
Cp,gas	349.04	J/mol×K	806.65	Joback Calculated Property

Similar Compounds

Find more compounds similar to Ethosuximide.

Mixtures

• Carbon dioxide + Ethosuximide

Sources

• Cheméo Relay (1.0)
• Crippen Method
• Crippen Method
• Experimental measurement and correlation of solubility of ethosuximide in supercritical carbon dioxide
• Joback Method
• McGowan Method
• NIST Webbook

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