- InChI
- InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m1/s1
- InChI Key
- CMWTZPSULFXXJA-SECBINFHSA-N
- Formula
- C14H14O3
- SMILES
- COc1ccc2cc(C(C)C(=O)O)ccc2c1
- Molecular Weight1
- 230.26
- CAS
- 22204-53-1
- Other Names
-
- (+)-2-(6-Methoxy-2-naphthyl)propionic acid
- (+)-2-(Methoxy-2-naphthyl)-propionic acid
- (+)-2-(Methoxy-2-naphthyl)-propionsaeure
- (+)-6-Methoxy-«alpha»-methyl-2-naphthaleneacetic acid
- (+)-6-Methoxy-«alpha»-methyl-2-napthaleneacetic acid
- (+)-6-Methoxy-«alpha»-methyl-2-naphthaleneacetic acid
- (+)-6-Methoxy-«alpha»-methyl-2-napthaleneacetic acid
- (+)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid
- (+)-Naproxen
- (S)-(+)-Naproxen
- (S)-2-(6-Methoxy-2-naphthyl)propionic acid
- (S)-6-Methoxy-«alpha»-methyl-2-naphthalene acetic acid
- (S)-6-Methoxy-«alpha»-methyl-2-naphthalene acetic acid
- (S)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid
- (S)-Naproxen
- 2-(6-Methoxy-2-naphthyl)propanoic acid , (+)-
- 2-Naphthaleneacetic acid, 6-methoxy-«alpha»-methyl-, (+)-
- 2-Naphthaleneacetic acid, 6-methoxy-«alpha»-methyl-, (S)-
- 2-Naphthaleneacetic acid, 6-methoxy-«alpha»-methyl-, (+)-
- 2-Naphthaleneacetic acid, 6-methoxy-«alpha»-methyl-, (S)-
- 6-Methoxy-«alpha»-methyl-2-naphthaleneacetic acid (naproxen)
- 6-Methoxy-«alpha»-methyl-2-naphthaleneacetic acid (naproxen)
- Apo-Naproxen
- Bonyl
- CG 3117
- Diocodal
- Dysmenalgit
- Equiproxen
- Floginax
- Laraflex
- Laser
- MNPA
- Naixan
- Napren
- Naprium
- Naprius
- Naprosine
- Naprosyn
- Naprosyne
- Naprux
- Naxen
- Naxyn
- Nycopren
- Panoxen
- Prexan
- Propionic acid, 2-(6-methoxy-2-naphthyl)-, (+)-
- Proxen
- Proxine
- RS-3540
- Reuxen
- Veradol
- Xenar
- d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure
- d-2-(6-Methoxy-2-naphthyl)propionic acid
- d-Naproxen
- ω : Acentric Factor.
- Cp,gas : Ideal gas heat capacity (J/mol×K).
- η : Dynamic viscosity (Pa×s).
- ΔfG° : Standard Gibbs free energy of formation (kJ/mol).
- ΔfH°gas : Enthalpy of formation at standard conditions (kJ/mol).
- ΔfusH° : Enthalpy of fusion at standard conditions (kJ/mol).
- ΔfusH : Enthalpy of fusion at a given temperature (kJ/mol).
- ΔsubH : Enthalpy of sublimation at a given temperature (kJ/mol).
- ΔvapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
- IE : Ionization energy (eV).
- log10WS : Log10 of Water solubility in mol/l.
- logPoct/wat : Octanol/Water partition coefficient.
- McVol : McGowan's characteristic volume (ml/mol).
- Pc : Critical Pressure (kPa).
- Inp : Non-polar retention indices.
- Tboil : Normal Boiling Point Temperature (K).
- Tc : Critical Temperature (K).
- Tfus : Normal melting (fusion) point (K).
- Vc : Critical Volume (m3/kmol).
- 1: Molecular weight from the IUPAC atomic weights tables.
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Physical Properties
| Property | Value | Unit | Source |
|---|---|---|---|
| ω | 0.7755 | Relay (1.0) Calculated Property | |
| ΔfG° | -106.38 | kJ/mol | Joback Calculated Property |
| ΔfH°gas | -426.52 | kJ/mol | Relay (1.0) Calculated Property |
| ΔfusH° | [29.00; 31.40] | kJ/mol |
|
| ΔfusH° | 29.00 | kJ/mol | Study of Glass Transition Phenomena in the Supercooled Liquid Phase of Methocarbamol, Acetaminophen and Mephensin |
| ΔfusH° | 31.40 | kJ/mol | Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2 |
| ΔvapH° | 99.00 | kJ/mol | Relay (1.0) Calculated Property |
| IE | 7.74 | eV | Relay (1.0) Calculated Property |
| log10WS | -4.50 | Aq. Solubility Prediction | |
| logPoct/wat | 3.036 | Crippen Calculated Property | |
| McVol | 178.210 | ml/mol | McGowan Calculated Property |
| Pc | 2859.68 | kPa | Joback Calculated Property |
| Inp | [2032.00; 2053.00] |
|
|
| Inp | 2032.00 | NIST | |
| Inp | 2053.00 | NIST | |
| Inp | 2032.00 | NIST | |
| Tboil | 639.34 | K | Relay (1.0) Calculated Property |
| Tc | 899.33 | K | Relay (1.0) Calculated Property |
| Tfus | [428.00; 430.65] | K |
|
| Tfus | 430.65 | K | Solubility of Anti-Inflammatory, Anti-Cancer, and Anti-HIV Drugs in Supercritical Carbon Dioxide |
| Tfus | 428.00 | K | Solubility of (+)-(S)-2-(6-Methoxynaphthalen-2-yl) Propanoic Acid in Acetone, Methanol, Ethanol, Propan-2-ol, and Ethyl Ethanoate at Temperatures between (278 and 320) K |
| Vc | 0.631 | m3/kmol | Relay (1.0) Calculated Property |
Temperature Dependent Properties
| Property | Value | Unit | Temperature (K) | Source |
|---|---|---|---|---|
| Cp,gas | [484.88; 544.11] | J/mol×K | [743.37; 958.25] |
|
| Cp,gas | 484.88 | J/mol×K | 743.37 | Joback Calculated Property |
| Cp,gas | 496.58 | J/mol×K | 779.18 | Joback Calculated Property |
| Cp,gas | 507.48 | J/mol×K | 815.00 | Joback Calculated Property |
| Cp,gas | 517.65 | J/mol×K | 850.81 | Joback Calculated Property |
| Cp,gas | 527.11 | J/mol×K | 886.62 | Joback Calculated Property |
| Cp,gas | 535.91 | J/mol×K | 922.44 | Joback Calculated Property |
| Cp,gas | 544.11 | J/mol×K | 958.25 | Joback Calculated Property |
| η | [0.0000547; 0.0010731] | Pa×s | [449.68; 743.37] |
|
| η | 0.0010731 | Pa×s | 449.68 | Joback Calculated Property |
| η | 0.0005122 | Pa×s | 498.63 | Joback Calculated Property |
| η | 0.0002791 | Pa×s | 547.58 | Joback Calculated Property |
| η | 0.0001680 | Pa×s | 596.52 | Joback Calculated Property |
| η | 0.0001092 | Pa×s | 645.47 | Joback Calculated Property |
| η | 0.0000754 | Pa×s | 694.42 | Joback Calculated Property |
| η | 0.0000547 | Pa×s | 743.37 | Joback Calculated Property |
| ΔfusH | [29.41; 34.20] | kJ/mol | [428.50; 439.20] |
|
| ΔfusH | 31.50 | kJ/mol | 428.50 | NIST |
| ΔfusH | 31.50 | kJ/mol | 428.50 | NIST |
| ΔfusH | 34.20 | kJ/mol | 428.80 | NIST |
| ΔfusH | 29.41 | kJ/mol | 439.20 | NIST |
| ΔsubH | 128.30 ± 0.50 | kJ/mol | 369.00 | NIST |
Similar Compounds
Find more compounds similar to Naproxen.
Mixtures
- 1-Propanol + Naproxen
- Isopropyl Alcohol + Naproxen
- Naproxen + Ethyl Acetate
- n-Hexane + Naproxen
- Naproxen + Carbon Tetrachloride
- Acetonitrile + Naproxen
- Naproxen + Benzene, chloro-
- Naproxen + Ethanol
- Trichloromethane + Naproxen
- Naproxen + Acetone
- Naproxen + Pentane
- Naproxen + Heptane
- Naproxen + Cyclohexane
- 1,2-Ethanediol + Naproxen
- Toluene + Naproxen
- Naproxen + Methyl Alcohol
- Carbon dioxide + Naproxen
- Naproxen + 1-Octanol
- Naproxen + Isopropyl myristate
- Naproxen + 1-Octanol + Water
Find more mixtures with Naproxen.
Sources
- Cheméo Relay (1.0)
- Crippen Method
- Solubility of naproxen in several organic solvents at different temperatures
- Thermodynamic study of the solubility of ibuprofen and naproxen in some ethanol + propylene glycol mixtures
- Solubility of naproxen in ethyl acetate + ethanol mixtures at several temperatures and correlation with the Jouyban-Acree model
- The determination and correlation of the solubility of naproxen in acetone and water mixtures
- High-pressure solubility of naproxen, nicotinamide and their mixture in acetone with supercritical CO2 as an anti-solvent
- Study of Glass Transition Phenomena in the Supercooled Liquid Phase of Methocarbamol, Acetaminophen and Mephensin
- Solubilities of Organic Semiconductors and Nonsteroidal Anti-inflammatory Drugs in Pure and Mixed Organic Solvents: Measurement and Modeling with Hansen Solubility Parameter
- Solubilities of the Drugs Benzocaine, Metronidazole Benzoate, and Naproxen in Supercritical Carbon Dioxide
- Solubility of Anti-Inflammatory, Anti-Cancer, and Anti-HIV Drugs in Supercritical Carbon Dioxide
- Solubility of (+)-(S)-2-(6-Methoxynaphthalen-2-yl) Propanoic Acid in Acetone, Methanol, Ethanol, Propan-2-ol, and Ethyl Ethanoate at Temperatures between (278 and 320) K
- Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2
- Joback Method
- Aqueous Solubility Prediction Method
- McGowan Method
- NIST Webbook
Note: Cheméo is only indexing the data, follow the source links to retrieve the latest data. The source is also providing more information like the publication year, authors and more. Take the time to validate and double check the source of the data.