Chemical Properties of Tromethamine (CAS 77-86-1)

InChI

InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI Key

LENZDBCJOHFCAS-UHFFFAOYSA-N

Formula

C4H11NO3

SMILES

NC(CO)(CO)CO

Molecular Weight¹

121.14

CAS

77-86-1

Other Names

• 1,3-propanediol, 2-amino-2-(hydroxymethyl)-
• 2-(Hydroxymethyl)-2-amino-1,3-propanediol
• 2-Amino-2-(hydroxymethyl)propane-1,3-diol
• 2-Amino-2-hydroxymethylpropanediol
• 2-Amino-2-methylol-1,3-propanediol
• 2-amino-2-(hydroxymethyl)-1,3-propanediol
• Addex-Tham
• Aminotri(hydroxymethyl)methane
• Aminotrimethylolmethane
• Aminotris(hydroxymethyl)methane
• Apiroserum Tham
• Methanamine, 1,1,1-tris(hydroxymethyl)-
• Methylamine, 1,1,1-tris(hydroxymethyl)-
• NSC 6365
• Pehanorm
• TAM
• THAM
• Talatrol
• Tham-E
• Trigmo base
• Triladyl
• Trimethylolaminomethane
• Tris
• Tris (buffering agent)
• Tris (hydroxymethyl)aminoethane
• Tris amino
• Tris base
• Tris buffer
• Tris(hydroxymethyl)aminomethane
• Tris(hydroxymethyl)methylamine
• Tris, free base
• Tris-steril
• Trisamin
• Trisamine
• Trisaminol
• Trispuffer
• Trizma
• Trizma base
• Trometamol
• Trometamole
• Tromethamin
• Tromethane
• Tromethanmin
• Tutofusin tris
• tris(hydroxymethyl)methanamine
• trishydroxymethylaminomethane

• Δ_cH°_solid : Standard solid enthalpy of combustion (kJ/mol).
• C_p,gas : Ideal gas heat capacity (J/mol×K).
• C_p,solid : Solid phase heat capacity (J/mol×K).
• Δ_fH°_solid : Solid phase enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• I_np : Non-polar retention indices.
• S°_{solid,1 bar} : Solid phase molar entropy at standard conditions (J/mol×K).
• T_boil : Normal Boiling Point Temperature (K).
• T_boilr : Boiling point at reduced pressure (K).
• T_fus : Normal melting (fusion) point (K).
• T_triple : Triple Point Temperature (K).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ΔcH°solid	[-2428.27; -2426.41]	kJ/mol
ΔcH°solid	-2426.41 ± 0.73	kJ/mol	NIST
ΔcH°solid	-2428.27 ± 0.78	kJ/mol	NIST
ΔfH°solid	-717.84 ± 0.82	kJ/mol	NIST
ΔfusH°	[33.48; 34.52]	kJ/mol
ΔfusH°	33.48	kJ/mol	Heat capacity measurement of organic thermal energy storage materials
ΔfusH°	34.52	kJ/mol	Thermal analysis of phase change materials in the temperature range 120.150 .C
logPoct/wat	-2.339		Crippen Calculated Property
McVol	94.810	ml/mol	McGowan Calculated Property
Inp	[1645.00; 1645.00]
Inp	1645.00		NIST
Inp	1645.00		NIST
S°solid,1 bar	175.44	J/mol×K	NIST
Tboil	621.66	K	Relay (1.0) Calculated Property
Tfus	[440.70; 445.15]	K
Tfus	445.15	K	Jean-Claude Bradley Open Melting Point Dataset (2014, CC0) Compiled value
Tfus	440.70 ± 3.00	K	NIST
Ttriple	443.60 ± 0.10	K	NIST

Cheméo can also estimate Critical Temperature, Critical Pressure, Critical Volume, Enthalpy of formation at standard conditions, Enthalpy of vaporization at standard conditions, Standard Gibbs free energy of formation, Acentric Factor, Ionization energy, Log10 of Water solubility in mol/l for this compound, but they fall outside the models' validated range, so they are not shown here. Open the prediction tool to compute them on demand.

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,solid	[167.19; 171.27]	J/mol×K	[298.15; 298.15]
Cp,solid	171.27	J/mol×K	298.15	NIST
Cp,solid	167.19	J/mol×K	298.15	NIST
ΔfusH	[2.41; 3.10]	kJ/mol	[443.60; 444.60]
ΔfusH	2.41	kJ/mol	443.60	NIST
ΔfusH	3.10	kJ/mol	444.60	NIST

Pressure Dependent Properties

Correlations

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[146.75; 319.14]	J/mol×K	[273.00; 1000.00]	Joback Predicted correlation
Equation			Y = A + B·T + C·T² + D·T³ + E·T⁴ Y is Cp,gas in J/mol×K, T in K
Coefficient A			-2.85700e+00
Coefficient B			6.73500e-01
Coefficient C			-5.00200e-04
Coefficient D			1.48700e-07
Coefficient E			0.00000e+00
Temperature range, min.			273.00
Temperature range, max.			1000.00
Cp,gas	146.75	J/mol×K	273.00	Calculated Property
Cp,gas	179.39	J/mol×K	353.78	Calculated Property
Cp,gas	207.56	J/mol×K	434.56	Calculated Property
Cp,gas	231.73	J/mol×K	515.33	Calculated Property
Cp,gas	252.38	J/mol×K	596.11	Calculated Property
Cp,gas	269.96	J/mol×K	676.89	Calculated Property
Cp,gas	284.96	J/mol×K	757.67	Calculated Property
Cp,gas	297.85	J/mol×K	838.44	Calculated Property
Cp,gas	309.08	J/mol×K	919.22	Calculated Property
Cp,gas	319.14	J/mol×K	1000.00	Calculated Property

Similar Compounds

Find more compounds similar to Tromethamine.

Mixtures

• Ethanol + Tromethamine + Water
• Ethanol, 2,2'-oxybis- + Tromethamine + Water
• Triethylene glycol + Tromethamine + Water
• Tetraethylene glycol + Tromethamine + Water
• Tromethamine + Water
• 2-Propanol, 2-methyl- + Tromethamine + Water
• 1-Propanol + Tromethamine + Water
• 2-Propanol + Tromethamine + Water
• Nitrous oxide + Tromethamine + Water
• Carbon dioxide + Tromethamine + Water
• Propylene Glycol + Tromethamine + Water
• Tromethamine + Water + 2-[2-(2-hydroxypropoxy)propoxy]-1-propanol
• Piperazine + Tromethamine + Water
• Tromethamine + Methyl Alcohol + Water
• Tromethamine + Methyl Alcohol
• Potassium bromide + Tromethamine + Water
• potassium chloride + Tromethamine + Water
• sodium chloride + Tromethamine + Water
• 1-Propanol + Tromethamine + Methyl Alcohol
• 1-Propanol + Tromethamine

Find more mixtures with Tromethamine.

Sources

• Jean-Claude Bradley Open Melting Point Dataset (2014, CC0) ChEDL chemicals 1.5.2, from Bradley, J.-C.; Williams, A.; Lang, A. Jean-Claude Bradley Open Melting Point Dataset. Figshare, 2014 (CC0).
• Cheméo Relay (1.0)
• Cheméo Relay (1.0, beta) Beta: served but experimental, data-limited and below our cross-validation release bar; the Joback value is recommended where available.
• Crippen Method
• Crippen Method
• Physical Properties and Thermal Decomposition of Aqueous Solutions of 2-Amino-2-hydroxymethyl-1,3-propanediol (AHPD)
• solubility of carbon dioxide in aqueous solutions of 2-aimno-2-hydroxymethyl-1,3-propanediol
• Buffer interactions: Solubilities and transfer free energies of TRIS, TAPS, TAPSO, and TABS from water to aqueous ethanol solutions
• Heat capacity measurement of organic thermal energy storage materials
• Enthalpy of absorption and limit of solubility of CO2 in aqueous solutions of 2-amino-2-hydroxymethyl-1,3-propanediol, 2-[2-(dimethyl-amino)ethoxy] ethanol, and 3-dimethyl-amino-1-propanol at T = (313.15 and 353.15) K and pressures up to 2 MPa
• Thermophysical property characterization of tris(hydroxymethyl)aminomethane
• Molar heat capacities of some aqueous 2-amino-2-hydroxymethyl-1,3-propanediol + glycol systems
• Thermophysical property characterization of ternary system containing {glycol (DEG/TEG/T4EG) + 2-amino-2-hydroxymethyl-1,3-propanediol + water}
• Isobaric vapour-liquid equilibrium of (tert-butanol + water) system with biological buffer TRIS at 101.3 kPa
• A green process for recovery of 1-propanol/2-propanol from their aqueous solutions: Experimental and MD simulation studies
• Thermal analysis of phase change materials in the temperature range 120.150 .C
• Determination of standard molar enthalpies of formation of Bi2Mo3O12 (s), Bi2MoO6 (s), Bi6Mo2O15 (s) and Bi6MoO12 (s) by solution calorimetry
• Physical Properties of Piperazine (PZ) Activated Aqueous Solutions of 2- Amino-2-hydroxymethyl-1, 3-propanediol (AHPD + PZ)
• Solubility Determination of Tris(hydroxymethyl)aminomethane in Water + Methanol Mixtures at Various Temperatures Using a Laser Monitoring Technique
• Solubility of Tris(hydroxymethyl)aminomethane in Water + 1-Propanol Mixtures at Various Temperatures
• Solubility of Tris(hydroxymethyl)aminomethane in Methanol + 1-Propanol Mixtures at Various Temperatures
• Solution Enthalpies of Ionic Liquid I-Hexyl-3-methylimidazolium Chloride
• Physicochemical Properties of Aqueous Solutions of 2-Amino-2-hydroxymethyl-1,3-propanediol
• Buffers and Ionic Salts: Densities and Solubilities of Aqueous and Electrolyte Solutions of Tris(hydroxymethyl)aminomethane and N-Tris[hydroxymethyl]-4-amino-butanesulfonic Acid
• Joback Method
• McGowan Method
• NIST Webbook

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