Chemical Properties of Hydrocortisone (CAS 50-23-7)

Hydrocortisone

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InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m1/s1
InChI Key
JYGXADMDTFJGBT-NDNUHCHRSA-N
Formula
C21H30O5
SMILES
CC12CC(O)C3C(CCC4=CC(=O)CCC43C)C1CCC2(O)C(=O)CO
Molecular Weight1
362.46
CAS
50-23-7
Other Names
  • 11,17,21-Trihydroxypregn-4-ene-3,20-dione, (11«beta»)-
  • 11Beta,17,21-trihydroxy progesterone
  • 11«beta»,17,21-Trihydroxypregn-4-ene-3,20-dione
  • 11«beta»,17,21-trihydroxyprogesterone
  • 11«beta»,17«alpha»,21-Trihydroxy-4-pregnene-3,20-dione
  • 11«beta»,17«alpha»,21-Trihydroxypregn-4-ene-3,20-dione
  • 11«beta»-Hydrocortisone
  • 11«beta»-Hydroxycortisone
  • 17-Hydroxycorticosterone
  • 17«alpha»-Hydroxycorticosterone
  • 4-Pregnen-11«beta»,17«alpha»,21-triol-3,20-dione
  • 4-Pregnene-11«beta»,17«alpha»,21-triol-3,20-dione
  • Acticort
  • Aeroseb HC
  • Ala-Scalp
  • Alacort
  • Anflam
  • Barseb HC
  • CaldeCort Spray
  • Cetacort
  • Cleiton
  • Cobadex
  • Compound F
  • Compound F (kendall)
  • Cort-Dome
  • Cortanal
  • Cortef
  • Cortenema
  • Corticreme
  • Cortifan
  • Cortiment
  • Cortisol
  • Cortisol alcohol
  • Cortispray
  • Cortolotion
  • Cortonema
  • Cortoxide
  • Cortril
  • Cremesone
  • Delacort
  • Dermacort
  • Dermocortal
  • Dermolate
  • Dihydrocostisone
  • Dioderm
  • Domolene-HC
  • Efcorbin
  • Efcortelan
  • Efcortelin
  • Eldecort
  • Eldercort
  • Epicort
  • Epiderm H
  • Esiderm H
  • Ficortril
  • Fiocortril
  • Genacort
  • H-Cort
  • HC
  • Heb-Cort
  • Hidro-Colisona
  • Hycort
  • Hycortol
  • Hycortole
  • Hydrasson
  • Hydro-Adreson
  • Hydro-colisona
  • Hydrocorticosterone
  • Hydrocortisone alcohol
  • Hydrocortisone free alcohol
  • Hydrocortistab
  • Hydrocortisyl
  • Hydrocortone
  • Hydroxycortisone
  • Hytone
  • Hytone lotion
  • Incortin-H
  • Incortin-hydrogen
  • Kendall's Compound F
  • Komed HC
  • Lacticare-HC
  • Maintasone
  • Medicort
  • Mildison
  • NSC 10483
  • Nutracort
  • Optef
  • Otosone-F
  • Penecort
  • Permicort
  • Polcort H
  • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11«beta»)-
  • Pregn-4-ene-3,20-dione, 11«beta»,17,21-trihydroxy-
  • Proctocort
  • Rectoid
  • Reichstein's Substance M
  • Scheroson F
  • Signef
  • Tarcortin
  • Texacort lotion 25
  • Topicort
  • Traumaide
  • U 1851
  • Zenoxone
  • anti-Inflammatory hormone
Sources

Physical Properties

Property Value Unit Source
Δcsolid -11480.00 ± 30.00 kJ/mol NIST
Δf -372.80 kJ/mol Joback Calculated Property
Δfgas -892.33 kJ/mol Joback Calculated Property
Δfus 30.71 kJ/mol Joback Calculated Property
Δvap 120.46 kJ/mol Joback Calculated Property
logPoct/wat 1.78 Crippen Calculated Property
Pc 2147.32 kPa Joback Calculated Property
Tboil 1117.27 K Joback Calculated Property
Tc 1367.94 K Joback Calculated Property
Tfus 753.46 K Joback Calculated Property
Vc 1.05 m3/kg-mol Joback Calculated Property

Temperature Dependent Properties

Property Value Unit Temperature (K) Source
Cp,gas 1185.49 J/mol×K 1117.27 Joback Calculated Property
ΔfusH 35.84 kJ/mol 486.0 NIST
ΔfusH 35.84 kJ/mol 486.0 NIST

Molecular Descriptors

Joback and Reid Groups
>C=O (nonring) 1
=CH- (ring) 1
-OH (alcohol) 3
=C< (ring) 1
-CH2- 1
-CH3 2
>C< (ring) 3
>C=O (ring) 1
>CH- (ring) 4
-CH2- (ring) 7

Similar Compounds

11Beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione. 2Alpha,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione. 6Alpha,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-doine. Pregn-4-ene-3,20-dione,11beta,17alpha,21-trihydroxy-,21 acetate. Hydrocortisone Acetate. Methylprednisolone. Prednisolone. 17Alpha,21dihydroxy progesterone. 17«alpha»-Hydroxyprogesterone. 17«alpha»-Hydroxyprogesterone. 11Beta,21-dihydroxypregn-4-ene-3,20-dione. Hydrocortamate. 11«alpha»-Hydroxy-17«alpha»-methyl testosterone. Cortisone. 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate.

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