Chemical Properties of 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE

InChI

InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChI Key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

Formula

C16H18FN3O3

SMILES

CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21

Molecular Weight¹

319.34

Other Names

• 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
• 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
• 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (norfloxacin)
• 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
• 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
• AM-715
• Baccidal
• Barazan
• Chibroxin
• Chibroxine
• Chibroxol
• Floxacin
• Fulgram
• Gonorcin
• Lexinor
• MK-366
• Noflo
• Nolicin
• Noracin
• Noraxin
• Norfloxacine
• Norocin
• Noroxin
• Noroxine
• Norxacin
• Sebercim
• Uroxacin
• Utinor
• Zoroxin
• norfloxacin

• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• T_fus : Normal melting (fusion) point (K).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Cheméo can also estimate Normal Boiling Point Temperature, Critical Temperature, Critical Pressure, Critical Volume, Enthalpy of formation at standard conditions, Enthalpy of vaporization at standard conditions, Standard Gibbs free energy of formation, Acentric Factor, Ionization energy for this compound, but they fall outside the models' validated range, so they are not shown here. Open the prediction tool to compute them on demand.

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
ΔfusH	[32.42; 32.97]	kJ/mol	[492.60; 500.20]
ΔfusH	32.42	kJ/mol	492.60	NIST
ΔfusH	32.97	kJ/mol	500.20	NIST

Similar Compounds

Find more compounds similar to 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE.

Mixtures

• Carbon dioxide + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Ethanol + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• 1-Butanol + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• 2-Propanol + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Acetone + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Acetonitrile + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Ethyl Acetate + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• n-Hexane + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Formamide, N,N-dimethyl- + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Formamide, N,N-dimethyl- + Ethyl Acetate + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• Water + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE
• 1-Octanol + 1-ETHYL-3-CARBOXY-6-FLUORO-7-(PIPERAZINYL-1)-QUINOLIN-4(1H)-ONE

Sources

• Cheméo Relay (1.0, beta) Beta: served but experimental, data-limited and below our cross-validation release bar; the Joback value is recommended where available.
• Crippen Method
• Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide
• Equilibrium study and diversified models of drug Norfloxacin in eight pure organic and binary solvents at T = (278.15 to 328.15) K
• Sublimation thermodynamics of four fluoroquinolone antimicrobial compounds
• Determination and Correlation for Solubilities of Ofloxacin, Norfloxacin, Lomefloxacin, Ciprofloxacin, Pefloxacin, and Pipemidic Acid in 1-Octanol from (293.15 to 333.15) K
• Aqueous Solubilities for Ofloxacin, Norfloxacin, Lomefloxacin, Ciprofloxacin, Pefloxacin, and Pipemidic Acid from (293.15 to 323.15) K
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

Note: Cheméo is only indexing the data, follow the source links to retrieve the latest data. The source is also providing more information like the publication year, authors and more. Take the time to validate and double check the source of the data.