Chemical Properties of Norfloxacin (CAS 70458-96-7)

InChI

InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChI Key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

Formula

C16H18FN3O3

SMILES

CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21

Molecular Weight¹

319.33

CAS

70458-96-7

Other Names

• 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
• 1-Ethyl-3-carboxy-6-fluoro-7-(piperazinyl-1)-quinolin-4(1H)-one
• 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
• 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (norfloxacin)
• 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
• 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
• AM-715
• Baccidal
• Barazan
• Chibroxin
• Chibroxine
• Chibroxol
• Floxacin
• Fulgram
• Gonorcin
• Lexinor
• MK-366
• Noflo
• Nolicin
• Noracin
• Noraxin
• Norfloxacine
• Norocin
• Noroxin
• Noroxine
• Norxacin
• Sebercim
• Uroxacin
• Utinor
• Zoroxin

• ω : Acentric Factor.
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• IE : Ionization energy (eV).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• T_boil : Normal Boiling Point Temperature (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
ΔfusH	[32.42; 32.97]	kJ/mol	[492.60; 500.20]
ΔfusH	32.42	kJ/mol	492.60	NIST
ΔfusH	32.97	kJ/mol	500.20	NIST

Similar Compounds

Find more compounds similar to Norfloxacin.

Mixtures

• Carbon dioxide + Norfloxacin
• Ethanol + Norfloxacin
• 1-Butanol + Norfloxacin
• Isopropyl Alcohol + Norfloxacin
• Acetone + Norfloxacin
• Acetonitrile + Norfloxacin
• Ethyl Acetate + Norfloxacin
• n-Hexane + Norfloxacin
• Formamide, N,N-dimethyl- + Norfloxacin
• Formamide, N,N-dimethyl- + Ethyl Acetate + Norfloxacin
• 1-Octanol + Norfloxacin
• Water + Norfloxacin

Sources

• Cheméo Relay (1.0)
• Cheméo Relay (1.0, beta) Beta: served but experimental, data-limited and below our cross-validation release bar; the Joback value is recommended where available.
• Crippen Method
• Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide
• Equilibrium study and diversified models of drug Norfloxacin in eight pure organic and binary solvents at T = (278.15 to 328.15) K
• Sublimation thermodynamics of four fluoroquinolone antimicrobial compounds
• Determination and Correlation for Solubilities of Ofloxacin, Norfloxacin, Lomefloxacin, Ciprofloxacin, Pefloxacin, and Pipemidic Acid in 1-Octanol from (293.15 to 333.15) K
• Aqueous Solubilities for Ofloxacin, Norfloxacin, Lomefloxacin, Ciprofloxacin, Pefloxacin, and Pipemidic Acid from (293.15 to 323.15) K
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

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