- InChI
- InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
- InChI Key
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N
- Formula
- C23H28ClN3O5S
- SMILES
-
COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(
=O)(=O)NC(=O)NC2CCCCC2)cc1 - Molecular Weight1
- 494.00
- CAS
- 10238-21-8
- Other Names
-
- 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea
- 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
- 5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
- 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide (glyburide)
- 5-chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
- 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
- Abbenclamide
- Adiab
- Apo-Glibenclamide
- Azuglucon
- Bastiverit
- Benclamin
- Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
- Betanase
- Daonil
- Diabeta
- Diabiphage
- Dibelet
- Duraglucon
- Euglucan
- Euglucon
- Euglucon 5
- Euglykon
- Gilemal
- Glibadone
- Glibenclamide
- Glibenil
- Glibens
- Glibil
- Glimel
- Glimide
- Glucolon
- Glybenzcyclamide
- Glynase
- HB 419
- HD 419
- Humedia
- Libanil
- Maninil
- Med-Glionil
- Melix
- Micronase
- N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
- N-(4-(«beta»-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
- N-(4-(«beta»-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
- Orabetic
- Pira
- Prodiabet
- Renabetic
- Semi-Daonil
- Suraben
- Tiabet
- U 26452
- UR 606
- Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-
- Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
- Yuglucon
- ω : Acentric Factor.
- Cp,gas : Ideal gas heat capacity (J/mol×K).
- ΔfG° : Standard Gibbs free energy of formation (kJ/mol).
- ΔfH°gas : Enthalpy of formation at standard conditions (kJ/mol).
- ΔfusH° : Enthalpy of fusion at standard conditions (kJ/mol).
- ΔfusH : Enthalpy of fusion at a given temperature (kJ/mol).
- ΔvapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
- IE : Ionization energy (eV).
- log10WS : Log10 of Water solubility in mol/l.
- logPoct/wat : Octanol/Water partition coefficient.
- McVol : McGowan's characteristic volume (ml/mol).
- Pc : Critical Pressure (kPa).
- Inp : Non-polar retention indices.
- Tboil : Normal Boiling Point Temperature (K).
- Tc : Critical Temperature (K).
- Tfus : Normal melting (fusion) point (K).
- Vc : Critical Volume (m3/kmol).
- 1: Molecular weight from the IUPAC atomic weights tables.
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Physical Properties
| Property | Value | Unit | Source |
|---|---|---|---|
| ω | 1.1270 | Relay (1.0) Calculated Property | |
| ΔfG° | -211.98 | kJ/mol | Joback Calculated Property |
| ΔfH°gas | -791.56 | kJ/mol | Relay (1.0) Calculated Property |
| ΔfusH° | 69.33 | kJ/mol | Joback Calculated Property |
| ΔvapH° | 160.60 | kJ/mol | Relay (1.0) Calculated Property |
| IE | 8.13 | eV | Relay (1.0) Calculated Property |
| log10WS | -5.09 | Aq. Solubility Prediction | |
| logPoct/wat | 3.642 | Crippen Calculated Property | |
| McVol | 355.830 | ml/mol | McGowan Calculated Property |
| Pc | 1829.41 | kPa | Joback Calculated Property |
| Inp | 3531.00 | NIST | |
| Tboil | 781.98 | K | Relay (1.0) Calculated Property |
| Tc | 1168.90 | K | Relay (1.0) Calculated Property |
| Tfus | [443.27; 446.98] | K |
|
| Tfus | 443.27 | K | Aq. Solubility Prediction |
| Tfus | 446.98 | K | Solubility Determination and Correlation of Glibenclamide in 11 Monosolvents and (Acetone + Acetonitrile) Binary Solvents from 283.15 K to 323.15 K |
| Vc | 1.220 | m3/kmol | Relay (1.0) Calculated Property |
Temperature Dependent Properties
| Property | Value | Unit | Temperature (K) | Source |
|---|---|---|---|---|
| Cp,gas | [1162.69; 1175.70] | J/mol×K | [1179.37; 1443.97] |
|
| Cp,gas | 1169.90 | J/mol×K | 1179.37 | Joback Calculated Property |
| Cp,gas | 1173.89 | J/mol×K | 1223.47 | Joback Calculated Property |
| Cp,gas | 1175.70 | J/mol×K | 1267.57 | Joback Calculated Property |
| Cp,gas | 1175.41 | J/mol×K | 1311.67 | Joback Calculated Property |
| Cp,gas | 1173.09 | J/mol×K | 1355.77 | Joback Calculated Property |
| Cp,gas | 1168.82 | J/mol×K | 1399.87 | Joback Calculated Property |
| Cp,gas | 1162.69 | J/mol×K | 1443.97 | Joback Calculated Property |
| ΔfusH | [46.30; 53.35] | kJ/mol | [446.80; 450.20] |
|
| ΔfusH | 46.30 | kJ/mol | 446.80 | NIST |
| ΔfusH | 53.35 | kJ/mol | 450.20 | NIST |
Similar Compounds
Find more compounds similar to Glyburide.
Mixtures
- Glyburide + Methyl Alcohol
- Glyburide + Ethanol
- Glyburide + 1-Propanol
- Glyburide + Isopropyl Alcohol
- Glyburide + 1-Butanol
- Glyburide + Acetone
- Glyburide + Acetonitrile
- Methyl Isobutyl Ketone + Glyburide
- Glyburide + Acetic acid, methyl ester
- Glyburide + Ethyl Acetate
- Glyburide + Acetonitrile + Acetone
Sources
- Cheméo Relay (1.0)
- Crippen Method
- Solubility Determination and Correlation of Glibenclamide in 11 Monosolvents and (Acetone + Acetonitrile) Binary Solvents from 283.15 K to 323.15 K
- Joback Method
- Aqueous Solubility Prediction Method
- McGowan Method
- NIST Webbook
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