Chemical Properties of Glyburide

InChI

InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

InChI Key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Formula

C23H28ClN3O5S

SMILES

COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1

Molecular Weight¹

494.01

Other Names

• 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea
• 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
• 5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
• 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide (glyburide)
• 5-chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
• 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
• Abbenclamide
• Adiab
• Apo-Glibenclamide
• Azuglucon
• Bastiverit
• Benclamin
• Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
• Betanase
• Daonil
• Diabeta
• Diabiphage
• Dibelet
• Duraglucon
• Euglucan
• Euglucon
• Euglucon 5
• Euglykon
• Gilemal
• Glibadone
• Glibenil
• Glibens
• Glibil
• Glimel
• Glimide
• Glucolon
• Glybenzcyclamide
• Glynase
• HB 419
• HD 419
• Humedia
• Libanil
• Maninil
• Med-Glionil
• Melix
• Micronase
• N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
• N-(4-(«beta»-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
• Orabetic
• Pira
• Prodiabet
• Renabetic
• Semi-Daonil
• Suraben
• Tiabet
• U 26452
• UR 606
• Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-
• Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
• Yuglucon
• glibenclamide

• C_p,gas : Ideal gas heat capacity (J/mol×K).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• I_np : Non-polar retention indices.
• T_fus : Normal melting (fusion) point (K).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ΔfusH°	69.33	kJ/mol	Joback Calculated Property
log10WS	-5.09		Aq. Solubility Prediction
logPoct/wat	3.642		Crippen Calculated Property
McVol	355.830	ml/mol	McGowan Calculated Property
Inp	[3531.00; 3531.00]
Inp	3531.00		NIST
Inp	3531.00		NIST
Tfus	[443.27; 446.98]	K
Tfus	446.98	K	Solubility Determination and Correlation of Glibenclamide in 11 Monosolvents and (Acetone + Acetonitrile) Binary Solvents from 283.15 K to 323.15 K
Tfus	443.27	K	Aq. Solubility Prediction

Cheméo can also estimate Normal Boiling Point Temperature, Critical Temperature, Critical Pressure, Critical Volume, Enthalpy of formation at standard conditions, Enthalpy of vaporization at standard conditions, Standard Gibbs free energy of formation, Acentric Factor, Ionization energy for this compound, but they fall outside the models' validated range, so they are not shown here. Open the prediction tool to compute them on demand.

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[1162.65; 1175.70]	J/mol×K	[1179.57; 1444.22]
Cp,gas	1169.92	J/mol×K	1179.57	Joback Calculated Property
Cp,gas	1173.90	J/mol×K	1223.68	Joback Calculated Property
Cp,gas	1175.70	J/mol×K	1267.79	Joback Calculated Property
Cp,gas	1175.40	J/mol×K	1311.89	Joback Calculated Property
Cp,gas	1173.07	J/mol×K	1356.00	Joback Calculated Property
Cp,gas	1168.80	J/mol×K	1400.11	Joback Calculated Property
Cp,gas	1162.65	J/mol×K	1444.22	Joback Calculated Property
ΔfusH	[46.30; 53.35]	kJ/mol	[446.80; 450.20]
ΔfusH	46.30	kJ/mol	446.80	NIST
ΔfusH	53.35	kJ/mol	450.20	NIST

Similar Compounds

Find more compounds similar to Glyburide.

Mixtures

• Glyburide + Methyl Alcohol
• Glyburide + Ethanol
• Glyburide + 1-Propanol
• Glyburide + 2-Propanol
• Glyburide + 1-Butanol
• Glyburide + Acetone
• Glyburide + Acetonitrile
• Methyl Isobutyl Ketone + Glyburide
• Glyburide + Acetic acid, methyl ester
• Glyburide + Ethyl Acetate
• Glyburide + Acetonitrile + Acetone

Sources

• Cheméo Relay (1.0, beta) Beta: served but experimental, data-limited and below our cross-validation release bar; the Joback value is recommended where available.
• Crippen Method
• Solubility Determination and Correlation of Glibenclamide in 11 Monosolvents and (Acetone + Acetonitrile) Binary Solvents from 283.15 K to 323.15 K
• Joback Method
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

Note: Cheméo is only indexing the data, follow the source links to retrieve the latest data. The source is also providing more information like the publication year, authors and more. Take the time to validate and double check the source of the data.
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